A combination of black seeds and turmeric at low doses showed enhanced efficacy in preventing metabolic syndrome in fructose fed rats

– GreenMedInfo Summary

Abstract Title:

Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats.

Abstract Source:

J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83. PMID: 25384193

Abstract Author(s):

Faridah Amin, Anwarul-Hassan Gilani, Malik Hassan Mehmood, Bina S Siddiqui, Nasima Khatoon

Article Affiliation:

Faridah Amin

Abstract:

Among noncommunicable diseases, metabolic syndrome (MS), a cluster of metabolic disorders including obesity, hyperglycemia, hyperlipidemia and hypertension, is highly prevalent in modern society. Its management requires lifestyle modifications and/or the life-long use of multiple medications, hence demanding development of safe alternative remedies. This study was aimed to establish the efficacy of combined use of black seeds and turmeric using fructose-fed rat model of MS. The high-performance liquid chromatographic fingerprints of turmeric and black seeds showed the presence of curcumin and thymoquinone, respectively, as their major constitutes. Different doses of black seeds and turmeric, individually and in combination, were administered to fructose-fed rats for up to 6 weeks representing characteristic features of MS. At 3 weeks of the treatment, black seeds and turmeric lowered (P<0.01) high blood pressure and low-density lipoprotein cholesterol, respectively, whereas their coadministration reduced (P<0.01) both high blood pressure and hypertriglyceridemia. At 6 weeks, the coadministration of both herbs, at half the doses of individual herbs, was the most effective (P<0.001) in preventing hypertension, hyperglycemia, dyslipidemia, hyperinsulinemia, and endothelial dysfunction than the individual herbs. This study demonstrates the therapeutic superiority of the combination of black seeds and turmeric at low doses over individually tested herbs, in improving features of MS.

Academic Cite:

Faridah Amin, Anwarul-Hassan Gilani, Malik Hassan Mehmood, Bina S Siddiqui, Nasima Khatoon. Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats. J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83.

Pubmed-Cite:

Faridah Amin, Anwarul-Hassan Gilani, Malik Hassan Mehmood, Bina S Siddiqui, Nasima Khatoon. Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats. J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83. PMID: 25384193

GMI-Cite:

Faridah Amin, Anwarul-Hassan Gilani, Malik Hassan Mehmood, Bina S Siddiqui, Nasima Khatoon. Coadministration of black seeds and turmeric shows enhanced efficacy in preventing metabolic syndrome in fructose-fed rats. J Cardiovasc Pharmacol. 2015 Feb ;65(2):176-83. PMID: 25384193

Article Published Date : Jan 31, 2015

Study Type : Animal Study

Additional Links

Substances : Nigella sativa (aka Black Seed) : CK(720) : AC(222), Turmeric : CK(5583) : AC(2569)

Diseases : Dyslipidemias : CK(391) : AC(75), Endothelial Dysfunction : CK(1210) : AC(237), Fructose-Induced Toxicity : CK(157) : AC(61), Hyperglycemia : CK(539) : AC(130), Hyperinsulinism : CK(251) : AC(56), Hypertension : CK(2984) : AC(406), Metabolic Diseases : CK(411) : AC(75)

Pharmacological Actions : Anticholesteremic Agents : CK(1459) : AC(264), Antihypertensive Agents : CK(1178) : AC(164), Hypoglycemic Agents : CK(1446) : AC(342), Hypolipidemic : CK(1288) : AC(265)

Additional Keywords : Natural Substance Synergy : CK(540) : AC(249), Risk Reduction : CK(6417) : AC(686)