– GreenMedInfo Summary
Click here to read the complete article.
Abstract Title:
Antitumor and Wound Healing Properties of Rubus ellipticus Smith.
Abstract Source:
J Acupunct Meridian Stud. 2015 Jun ;8(3):134-41. Epub 2013 Nov 6. PMID: 26100067
Abstract Author(s):
Blassan Plackal George, Thangaraj Parimelazhagan, Yamini T Kumar, Thankarajan Sajeesh
Article Affiliation:
Blassan Plackal George
Abstract:
The present investigation has been undertaken to study the antioxidant, antitumor, and wound healing properties of Rubus ellipticus. The R. ellipticus leaves were extracted using organic solvents in Soxhlet and were subjected to in vitro antioxidant assays. R. ellipticus leaf methanol (RELM) extract, which showed higher in vitro antioxidant activity, was taken for the evaluation of in vivo antioxidant, antitumor, and wound healing properties. Acute oral and dermal toxicity studies showed the safety of RELM up to a dose of2 g/kg. A significant wound healing property was observed in incision, excision, and Staphylococcus aureus-induced infected wound models in the treatment groups compared to the control group. A complete epithelialization period was noticed during the 13(th) day and the 19(th) day. A 250-mg/kg treatment was found to prolong the life span of mice with Ehrlich ascite carcinoma (EAC; 46.76%) and to reduce the volume of Dalton’s lymphoma ascite (DLA) solid tumors (2.56 cm(3)). The present study suggests that R. ellipticus is a valuable natural antioxidant and that it is immensely effective for treating skin diseases, wounds, and tumors.
Academic Cite:
Blassan Plackal George, Thangaraj Parimelazhagan, Yamini T Kumar, Thankarajan Sajeesh. Antitumor and Wound Healing Properties of Rubus ellipticus Smith. J Acupunct Meridian Stud. 2015 Jun ;8(3):134-41. Epub 2013 Nov 6.
Pubmed-Cite:
Blassan Plackal George, Thangaraj Parimelazhagan, Yamini T Kumar, Thankarajan Sajeesh. Antitumor and Wound Healing Properties of Rubus ellipticus Smith. J Acupunct Meridian Stud. 2015 Jun ;8(3):134-41. Epub 2013 Nov 6. PMID: 26100067
GMI-Cite:
Blassan Plackal George, Thangaraj Parimelazhagan, Yamini T Kumar, Thankarajan Sajeesh. Antitumor and Wound Healing Properties of Rubus ellipticus Smith. J Acupunct Meridian Stud. 2015 Jun ;8(3):134-41. Epub 2013 Nov 6. PMID: 26100067
Article Published Date : May 31, 2015
Study Type : Animal Study
Additional Links
Substances : Raspberry : CK(47) : AC(32)
Diseases : Dalton’s Ascitic Lymphoma : CK(4) : AC(2), Ehrlich carcinoma : CK(17) : AC(9), Wound Healing : CK(539) : AC(161)
Pharmacological Actions : Antioxidants : CK(8430) : AC(3132), Antiproliferative : CK(2546) : AC(1685)
No Comments Yet