– GreenMedInfo Summary
Abstract Title:
Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial.
Abstract Source:
Nutrition. 2016 Apr ;32(4):461-7. Epub 2015 Nov 6. PMID: 26740254
Abstract Author(s):
Han Saem Jeong, Soon Jun Hong, Jae Young Cho, Tae-Bum Lee, Ji-Wung Kwon, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Article Affiliation:
Han Saem Jeong
Abstract:
OBJECTIVE: Black raspberry (Rubus occidentalis) is known for improving vascular function. However, there has been no study evaluating its effects on 24-h systolic and diastolic blood pressure in prehypertensive patients. The aim of this study was to examine those effects.
METHODS: Patients with prehypertension (N = 45) were prospectively randomized into a moderate-dose black raspberry group (n = 15, 1500 mg/d), a high-dose black raspberry group (n = 15, 2500 mg/d), or a placebo group (n = 15) during an 8-wk follow-up period. Raspberries were consumed in the form of a dried powder extract that wasfashioned into capsules. The capsules contained 187.5 and 312.5 mg of raspberry powder, which was equivalent to 1500 and 2500 mg raspberries. Ambulatory 24-h blood pressure (BP); central BP; pulse-wave velocity; abdominal visceral fat; serum renin; angiotensin-converting enzyme; and inflammatory cytokines such as interleukin-6, tumor necrosis factor-α, C-reactive protein, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and plasminogen activator inhibitor-1 were measured at baseline and at 8-wk follow-up.
RESULTS: High-dose black raspberry significantly reduced 24-h systolic blood pressure (SBP; 3.3 ± 10 mm Hg versus -6.7 ± 11.8 mm Hg; P < 0.05) and nighttime SBP (5.4 ± 10.6 mm Hg versus -4.5 ± 11.3 mm Hg; P < 0.05) compared with controls during the 8-wk follow-up. Black raspberry powder did not produce any significant changes in most of the parameters other than BP.
CONCLUSION: The use of black raspberry significantly lowered 24-h BP in prehypertensive patients during the 8-wk follow-up. Black raspberry used as a dietary supplement could be beneficial in reducing SBP in prehypertensive patients.
Academic Cite:
Han Saem Jeong, Soon Jun Hong, Jae Young Cho, Tae-Bum Lee, Ji-Wung Kwon, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim. Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial.Nutrition. 2016 Apr ;32(4):461-7. Epub 2015 Nov 6.
Pubmed-Cite:
Han Saem Jeong, Soon Jun Hong, Jae Young Cho, Tae-Bum Lee, Ji-Wung Kwon, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim. Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial.Nutrition. 2016 Apr ;32(4):461-7. Epub 2015 Nov 6. PMID: 26740254
GMI-Cite:
Han Saem Jeong, Soon Jun Hong, Jae Young Cho, Tae-Bum Lee, Ji-Wung Kwon, Hyung Joon Joo, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim. Effects of Rubus occidentalis extract on blood pressure in patients with prehypertension: Randomized, double-blinded, placebo-controlled clinical trial.Nutrition. 2016 Apr ;32(4):461-7. Epub 2015 Nov 6. PMID: 26740254
Article Published Date : Mar 31, 2016
Study Type : Human Study
Additional Links
Substances : Black Raspberry : CK(114) : AC(33)
Diseases : Prehypertension : CK(114) : AC(11)
Pharmacological Actions : Antihypertensive Agents : CK(1178) : AC(164)
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