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Abstract Title:
Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial.
Abstract Source:
Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27279471
Abstract Author(s):
Jee Hyun An, Dong-Lim Kim, Tae-Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi, Sin Gon Kim
Article Affiliation:
Jee Hyun An
Abstract:
Rubus occidentalis (RO) has beneficial effects on glucose and lipid profiles in vitro. The aim of the study was to investigate RO extract effect on metabolic parameters in prediabetic patients, adopting a 12-week, randomized, double-blind, placebo-controlled trial. Forty-four patients (age 59.0 ± 8.2 years, 70.5% females, HbA1c 5.8 ± 0.4%) were divided into placebo (n = 13), low-dose RO extract (LRE; n = 14), or high-dose RO extract (HRE; n = 17) groups. Either 900 or 1800 mg per day of RO extract was administered orally. Area under the curve for glucose obtained2 h after a 75-g oral glucose tolerance test was significantly decreased in the HRE group, compared with the placebo group (-28.1 ± 42.4 vs. +13.4 ± 52.6 mg/dL, p < 0.05). Homoeostasis model assessment-B was increased (+17.11 ± 10.69, +5.24 ± 4.10, and +0.86 ± 6.01 in HRE, LRE, and placebo, respectively, p < 0.05). Serum levels of monocyte chemoattractant protein-1 and oxidized low-density lipoprotein were significantly decreased by treatment in a dose-dependent manner (monocyte chemoattractant protein-1: -35.0 ± 21.2, +8.4 ± 18.1, and +24.2 ± 14.5; oxidized low-density lipoprotein: -19.7 ± 8.5, -13.1 ± 7.2, and -2.2 ± 11.0 in the HRE, LRE, and placebo, respectively, p < 0.05). The results support the beneficial effects of RO extract on the control of glycemia and vascular inflammation in prediabetic patients. (ClinicalTrials.gov: NCT01964703). Copyright © 2016 John Wiley&Sons, Ltd.
Academic Cite:
Jee Hyun An, Dong-Lim Kim, Tae-Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi, Sin Gon Kim. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. Phytother Res. 2016 Jun 9. Epub 2016 Jun 9.
Pubmed-Cite:
Jee Hyun An, Dong-Lim Kim, Tae-Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi, Sin Gon Kim. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27279471
GMI-Cite:
Jee Hyun An, Dong-Lim Kim, Tae-Bum Lee, Kyeong Jin Kim, Sun Hwa Kim, Nam Hoon Kim, Hee Young Kim, Dong Seop Choi, Sin Gon Kim. Effect of Rubus Occidentalis Extract on Metabolic Parameters in Subjects with Prediabetes: A Proof-of-concept, Randomized, Double-blind, Placebo-controlled Clinical Trial. Phytother Res. 2016 Jun 9. Epub 2016 Jun 9. PMID: 27279471
Article Published Date : Jun 08, 2016
Study Type : Human Study
Additional Links
Substances : Black Raspberry : CK(114) : AC(33)
Diseases : Prediabetes : CK(192) : AC(23)
Pharmacological Actions : Anti-Inflammatory Agents : CK(4861) : AC(1630), Hypoglycemic Agents : CK(1446) : AC(342)
Additional Keywords : Dose Response : CK(1519) : AC(574), Plant Extracts : CK(7645) : AC(2539)
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