The present work emphasizes the potential of berries in chemoprevention, especially CRC chemoprevention.

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Abstract Title:

Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer.

Abstract Source:

Oxid Med Cell Longev. 2015;2015:154164. Epub 2015 Jun 9. PMID: 26180579

Abstract Author(s):

Carole Minker, Livine Duban, Daniel Karas, Päivi Järvinen, Annelise Lobstein, Christian D Muller

Article Affiliation:

Carole Minker

Abstract:

Scope. The aim of this work is to identify which proapoptotic pathway is induced in human colon cancer cell lines, in contact with proanthocyanidins extracted from various berries. Methods and Results. Proanthocyanidins (Pcys) extracted from 11 berry species are monitored for proapoptotic activities on two related human colon cancer cell lines: SW480-TRAIL-sensitive and SW620-TRAIL-resistant. Apoptosis induction is monitored by cell surface phosphatidylserine (PS) detection. Lowbush blueberry extract triggers the strongest activity. When tested on the human monocytic cell line THP-1, blueberry Pcys are less effective for PS externalisation and DNA fragmentation is absent, highlighting a specificity of apoptosis induction in gut cells. In Pcys-treated gut cell lines, caspase 8 (apoptosis extrinsic pathway) but not caspase 9 (apoptosis intrinsic pathway) is activated after 3 hours through P38 phosphorylation (90 min), emphasizing the potency of lowbush blueberry Pcys to eradicate gut TRAIL-resistant cancer cells. Conclusion. We highlight here that berries Pcys, especially lowbush blueberry Pcys, are of putative interest for nutritional chemoprevention of colorectal cancer in view of their apoptosis induction in a human colorectal cancer cell lines.

Academic Cite:

Carole Minker, Livine Duban, Daniel Karas, Päivi Järvinen, Annelise Lobstein, Christian D Muller. Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. Oxid Med Cell Longev. 2015;2015:154164. Epub 2015 Jun 9.

Pubmed-Cite:

Carole Minker, Livine Duban, Daniel Karas, Päivi Järvinen, Annelise Lobstein, Christian D Muller. Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. Oxid Med Cell Longev. 2015;2015:154164. Epub 2015 Jun 9. PMID: 26180579

GMI-Cite:

Carole Minker, Livine Duban, Daniel Karas, Päivi Järvinen, Annelise Lobstein, Christian D Muller. Impact of Procyanidins from Different Berries on Caspase 8 Activation in Colon Cancer. Oxid Med Cell Longev. 2015;2015:154164. Epub 2015 Jun 9. PMID: 26180579

Article Published Date : Dec 31, 2014

Study Type : Human In Vitro

Additional Links

Substances : Black Currant : CK(162) : AC(31), Blackberry : CK(35) : AC(24), Blueberry : CK(334) : AC(112), Cranberry : CK(349) : AC(69), Indian Gooseberry : CK(7) : AC(3), Lingonberry : CK(31) : AC(12), Raspberry : CK(47) : AC(32)

Diseases : Colon Cancer : CK(749) : AC(430), Colon Cancer: Prevention : CK(178) : AC(57)

Pharmacological Actions : Apoptotic : CK(2958) : AC(2075), Caspase-8 activation : CK(27) : AC(6), Chemopreventive : CK(2835) : AC(787)

Additional Keywords : Dietary Concentrations : CK(95) : AC(23), Growing Your Own Food : CK(14) : AC(10), Procyanidins : CK(8) : AC(4)